peprotech Human TGF-beta2-Mammalian

peprotech Human TGF-beta2-Mammalian

转化生长因子、胶质母细胞瘤来源的T细胞YZ因子，BSC-1，转移生长因子β-2，polyergi

Description :

描述：

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β2 has been shown to exert suppressive effects on IL-2 dependent T-cell growth, and may also have an autocrine function in enhancing tumor growth by suppressing immuno-surveillance of tumor development. Recombinant human TGF-β2 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

peprotech Human TGF-beta2-Mammalian三哺乳动物亚型TGF-ββ，TGF-ββ1，β2，β3，信号通过相同的受体具有类似的生物学效应。它们是多功能的细胞因子，调节细胞增殖，生长，分化和运动，以及细胞外基质的合成和沉积。它们参与了各种生理过程，包括胚胎发育、组织重塑和伤口愈合。它们被分泌主要是作为潜在的复合物，它被存储在细胞表面和细胞外基质中。生物活性释放TGF-β亚型β从潜在的复杂的涉及到蛋白质如血小板反应蛋白的构象变化的复杂和/或诱导蛋白水解处理。TGF-ββ2已被证明对IL-2依赖性T细胞生长的YZ作用，还可能通过YZ肿瘤发展，提高免疫监视肿瘤生长有分泌功能。重组人转化生长因子-β2是一个25 kDa蛋白由两个完全相同的112个氨基酸的多肽链由一个单一的二硫

Catalog #:

目录#：

100-35B

Source :

来源：

A293 cells

Purity :

纯度：

Greater than 98% by SDS-PAGE gel and HPLC analyses

大于98%的SDS-PAGE凝胶电泳和GX液相色谱分析

Endotoxin Level :

内毒素水平：

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

内毒素水平低于0.1毫微克每μG（1eu /μG）

Biological Activity :

生物活性：

Determined by its ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The ED 50 was found to be ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.

通过其YZ小鼠HT-2细胞小鼠IL-4依赖增殖能力的测定。ED 50被认为是≤0.2毫微克/毫升，对应于一个特定的≥5×106单位/毫克的活性。

Selected References :

选定引用：

Selected List of References Citing This Product

引用该产品的引用列表

AA Sequence :

氨基酸序列：

ALDAAYCFRN VQDNCCLRPL YIDFKRDLGW KWIHEPKGYN ANFCAGACPY LWSSDTQHSR VLSLYNTINP EASASPCCVS QDLEPLTILY YIGKTPKIEQ LSNMIVKSCK CS

aldaaycfrn vqdncclrpl yidfkrdlgw kwihepkgyn anfcagacpy lwssdtqhsr vlslyntinp easaspccvs qdlepltily yigktpkieq lsnmivksck CS

PubMed Link :

PubMed链接：

TGF+AND+beta+AND+2

TGFβ+ +和+

Country of Origin :

原产国：

USA

美国

Special Sizes:

特殊尺寸：

Many products can be ordered in custom sizes. Please click here to contact with your request.

许多产品可以订购定制的尺寸。请点击这里您的要求。

Usage:

使用：

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

仅用于研究。不用于诊断或ZL程序。

上海江林生物拥有自己强大的细胞库，产品种属众多。另外公司长期经营ELISA试剂盒、生化试剂、胎牛血清、细胞株、细胞因子、标准品、MGB探针及其他技术实验服务等。价格实惠，质量保证。产品价格及说明书和其他详细信息请直接与我们。

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