Peprotech Recombinant Murine IL-13厂家直销_详细资料

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Peprotech Recombinant Murine IL-13厂家直销
Catalog Number:
210-13
Synonyms:
NC300 （Human） P600 （Murine）
Description:
IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, ａnd also by mast cells ａnd NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development ａnd indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes ａnd macrophages ａnd it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 ａnd IL-8. IL-13 has also been shown to enhance B cell proliferation ａnd to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human ａnd murine IL-13 is cross-species reactive. Recombinant murine IL-13 is a 12.3 kDa protein consisting of 111 amino acid residues.
AA Sequence:
MPVPRSVSLP LTLKELIEEL SNITQDQTPL CNGSMVWSVD LAAGGFCVAL DSLTNISNCN AIYRTQRILH GLCNRKAPTT VSSLPDTKIE VAHFITKLLS YTKQLFRHGP F
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
Biological Activity:
The ED₅₀ as determined by the dose-dependent proliferation of TF-1 cells was < 4.0 ng/ml, corresponding to a specific activity of > 2.5 x 10⁵units/mg.

Cross Reactivity:
Human, Mouse
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