磷酸化干扰素调节因子3抗体 Anti-phospho-IRF3（Ser...

磷酸化干扰素调节因子3抗体Anti-phospho-IRF3（Ser386）的产品说明（为您现货供应，详询）：
--产品介绍：Mediates interferon-stimulated response element （ISRE） promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein （CREBBP） to form dsRNA-activated factor 1 （DRAF1）, a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.Subcellular Location : Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.Tissue Specificity : Expressed constitutively in a variety of tissues.干扰素调节因子家族是一大类对干扰素起调控作用的转录因子的统称。 一般认为干扰素调节因子（IRF）通过调节干扰素的表达而行使其抗病毒、应激、免疫调节功能。近年来，研究人员发现IRF在细胞凋亡、细胞周期、细胞分化、肿瘤发生中也起着重要的调节作用。
--该抗体来源于：（Rabbit）
--磷酸化干扰素调节因子3抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, mo, rat
3、产品类型：一抗磷酸化抗体
4、研究领域：肿瘤细胞生物细胞凋亡转录调节因子表观遗传学
5、蛋白分子量：predicted molecular weight: 47kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from hu phospho-IRF3（Ser386）
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
11、产品应用：WB=1:100-500ELISA=1:500-1000IHC-P=1:100-500IHC-F=1:100-500Flow-Cyt=1:20-100IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

（1mg/1ml磷酸化干扰素调节因子3抗体Anti-phospho-IRF3（Ser386），的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）

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