脂联素受体1抗体 Anti-Adiponectin Receptor ...

脂联素受体1抗体Anti-Adiponectin Receptor 1的产品说明：
--产品介绍：Acrp30 is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR- . Cloning of complementary DNAs encoding adiponectin receptors 1 and 2 （AdipoR1 and AdipoR2） have shown that AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver.Subcellular Location : Membrane; Multi-pass membrane protein. Note=Localized to the cell membrane and intracellular organelles.Tissue Specificity : Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.Similarity : Belongs to the ADIPOR family.Subunit : May form homo and heteromultimers.脂联素与受体结合后具有增强胰岛素敏感性，抗高血糖，抗动脉粥样硬化等生物学效应，任何增加或减少脂联素及其受体表达的方法都影响这些疾病的发生和发展. 脂联素受体-1（AdipoR1和AdipoR2）同属于PAQR家族，具有七次跨膜蛋白的特有结构，mol wt:41kDa
--该抗体来源于：（Rabbit）
--脂联素受体1抗体的参数介绍：
1、浓度：1mg/1ml
2、交叉反应：hu, rat, mo, Rb, dog
3、产品类型：一抗
4、研究领域：免疫学生长因子和激素糖尿病内分泌病
5、蛋白分子量：predicted molecular weight: 41kDa
6、性状：Lyophilized or Liquid
7、免疫原：KLH conjugated synthetic peptide derived from human Adiponectin Receptor 1 C-terminus
8、亚型：polyclonal
9、纯化方法：affinity purified by Protein A
10、储存液：0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
11、产品应用：WB=1:100-500ELISA=1:500-1000IP=1:20-100IHC-P=1:100-500IHC-F=1:100-500IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
12、保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

（1mg/1ml脂联素受体1抗体Anti-Adiponectin Receptor 1，的相关产品：免疫组化常用试剂免疫印迹常用试剂各种标记二抗）