AZD8055(1009298-09-2)(≥99%)

特别提示：包括AZD8055在内，本公司的所有产品仅可用于科研实验，严禁用于临床YL及其他非科研用途！

产品名称：AZD8055
英文名称：AZD8055
产品货号：L10089
产品规格：10mg|50mg
 属性

CAS号	1009298-09-2
分子式	C25H31N5O4
分子量	465.56
溶解性	DMSO ≥90mg/mL Water ≥1.8mg/mL Ethanol ≥13mg/mL
存贮条件	储存温度-20℃
密度	1.2480

描述

产品介绍	AZD8055是ATP竞争性mTORYZ剂，IC50为0.8 nM，比对PI3K和ATM/DNA-PK的YZ性强超过1000倍。
备注	AZD8055 is a novel ATP-competitivemTORinhibitor withIC50of 0.8 nM with excellent selectivity(?1,000-fold) against PI3K isoforms and ATM/DNA-PK.Phase 1.
生化机理	AZD8055 shows low activity(～1,000-fold) against all PI3K isoforms(α,β,γ,δ) and other members of the PI3K-like kinase family(ATM and DNA-PK).AZD8055 inhibits the phosphorylation of mTORC1(p70S6K and 4E-BP1) as well as phosphorylation of the mTORC2(Akt) and downstream proteins.The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 can be fully inhibited by AZD8055,resulting in significant inhibition of cap-dependent translation.AZD8055 potently inhibits proliferation in U87MG,A549 and H838 cells with IC50 of 53,50 and 20 nM,respectively.AZD8055 also induces autophagy and increased LC3-II levels in H838 and A549 cells[1].AZD8055 decreases AML blast cell proliferation and cell cycle progression,reduces the clonogenic growth of leukemic progenitors and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells
别名	(5-(2,4-二((3S)-3-甲基mǎ啉-4-基)吡dìng并(2,3-d)嘧啶-7-基)-2-jiǎ氧基苯基)jiǎ醇;;AZD8055;AZD 8055;(5-(2,4-bis((3s)-3-methylmorpholin-4-yl)pyrido(2,3-d)pyrimidin-7-yl)-2-methoxyphenyl)methanol

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