Bombesin Receptor 2 (extracellular) Antibody

分子量：
43199 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Battey, J.F. et al. (1991) Proc Natl Acad Sci USA 88, 395.2. Kroog, G.S. et al.(1995) Med. Res. Rev. 15, 389.3. Ohki-Hamazaki, H. et al. (2005) Int. J. Dev. Biol. 49, 293.4. Reubi, J.C. (2003) Endocr. Rev. 24, 389.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Bombesin Receptor 2 (extracellular) antibody.
功能：

总结：
Bombesin receptor 2 (BB2) is a member of a family of receptors that binds the 14 amino acid peptide, bombesin. Bombesin was first isolated from frog skin and it was later established that mammals express endogenous bombesin-like peptides such as gastrin-releasing peptide (GRP; a 27 amino acid homologue) and neuromedin B (NMB; a 10 amino acid homologue).BB2 is the preferred receptor for GRP and hence it is also referred to as GRP receptor or GRP-R.1 BB1 is the preferred receptor for NMB and therefore it is also known as NMB-R. A third member (called BB3) of the bombesin receptor family has been recognized but the endogenous mammalian ligand for this receptor remains to be identified.All three bombesin receptors are members of the seven-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. BB2 is coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), intracellular Ca2+ mobilization, and cell growth.2GRP (through its binding to BB2) plays an essential role in the release of hormones in the intestinal tract, the regulation of smooth muscle contraction, and the secretion of pancreatic enzymes.2 In the brain, BB2 has been implicated in regulating feeding behavior, thermoregulation, and memory formation.3Finally, BB2 is overexpressed in several human tumors including breast, prostate, and lung, where it acts as a growth factor receptor inducing tumor growth. BB2 is considered a potential target for the development of both diagnostics and anti-cancer therapies.4Abgent is pleased to offer a highly specificantibody directed against an epitope located in the 3rd extracellular loop of the human BB2 receptor. Anti-Bombesin Receptor2 (extracellular)antibody(#AG1369) can be used in western blot analysis, as well asimmunocytochemical and immunohistochemical applications, and will recognize BB2 from human, rat, mouse, and dog samples.
联系方式：

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京经济技术开发区永昌中路4号院4号楼3层