A3 Adenosine Receptor Antibody

分子量：
36185 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
1. Okusa, M.D. (2002) Am. J. Physiol. Renal Physiol. 282, F10.2. Fredholm, B.B. et al. (2001) Pharmacol. Rev. 53, 527.3. Nakata, H. (1989) J. Biol. Chem. 264, 165454. Baraldi, P.G. et al. (2006) Curr. Med. Chem. 13, 3467.5. Headrick, J.P. et al. (2003) Am. J. Physiol. Heart Circ. Physiol. 285, H1797.6. Madi, L. et al. (2004) Clin. Cancer Res. 10, 4472.7. Ochaion, A. et al. (2007) Ann. Rheum. Dis. 66, 446.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality A3 Adenosine Receptor antibody.
功能：

总结：
Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine receptor (A1AR), A2A-Adenosine receptor (A2AAR), A2B-Adenosine receptor (A2BAR), and A3-Adenosine receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4However, all are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3Expression of A3AR has been reported in brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases. Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of human A3 Adenosine receptor (A3AR). Anti-A3 Adenosine Receptor antibody (#AG1384) can be used in western blot analysis, as well as immunocytochemical and immunohistocemical applications, and has been designed to recognize A3 Adenosine receptor from human, rat, and mouse samples.
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