A3 Adenosine Receptor Antibody | LBP71225 | Leading Biology

商品分类：多克隆抗体

产品概述：Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine receptor (A1AR), A2A-Adenosine receptor (A2AAR), A2B-Adenosine receptor (A2BAR), and A3-Adenosine receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4However, all are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3Expression of A3AR has been reported in brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases. Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of human A3 Adenosine receptor (A3AR). Anti-A3 Adenosine Receptor antibody (#AG1384) can be used in western blot analysis, as well as immunocytochemical and immunohistocemical applications, and has been designed to recognize A3 Adenosine receptor from human, rat, and mouse samples.

靶点/蛋白：Peptide (C)KETGAFYGREFKTAK, corresponding to amino acid residues 216-230 of human A3AR (Accession P33765). 3rd intracellular loop.

来源：Rabbit

存储溶液：Affinity purified antibody, lyophilized powder

参考文献：1. Okusa, M.D. (2002) Am. J. Physiol. Renal Physiol. 282, F10.2. Fredholm, B.B. et al. (2001) Pharmacol. Rev. 53, 527.3. Nakata, H. (1989) J. Biol. Chem. 264, 165454. Baraldi, P.G. et al. (2006) Curr. Med. Chem. 13, 3467.5. Headrick, J.P. et al. (2003) Am. J. Physiol. Heart Circ. Physiol. 285, H1797.6. Madi, L. et al. (2004) Clin. Cancer Res. 10, 4472.7. Ochaion, A. et al. (2007) Ann. Rheum. Dis. 66, 446.

特异性：Human, Rat

别名：Adenosine receptor A3, ADORA3

应用：WB~~1:200-1:2000IHC~~1:50ICC~~1:100

简单描述：Rabbit Polyclonal A3 Adenosine Receptor Antibody. Validated for use in WB, IHC, ICC.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层