Human BLT1 (extracellular) Antibody

分子量：
37557 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Riccioni, G. et al. (2008) J. Leukoc. Biol. 84, 1374.2. Tager, A.M. and Luster A.D. (2003) Prostaglandins Leukot. Essent. Fatty Acids 69, 123.3. Yokomizo, T. et al. (1997) Nature 387, 620.4. Owman, C. et al. (1996) Genomics 37, 187.5. Yokomizo, T. et al. (2000) J. Exp. Med. 192, 421.6. Tryselius, Y. et al. (2000) Biochem. Biophys. Res. Commun. 274, 377.7. Kamohara, M. et al. (2000) J. Biol. Chem. 275, 27000.8. Wang, S. et al. (2000) J. Biol. Chem. 275, 39482.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Human BLT1 (extracellular) antibody.
功能：

总结：
Leukotrienes (LTs) are lipid mediators prominently exerting proinflammatory responses. They are divided in two classes: cysteinyl LTs (cysLTs) which have a thioester linkage and LTB41. LTB4, a chemoattractant plays a prominent role in the recruitment and activation of leukocytes2.LTB4 acts through two receptors whichbelong to the G-protein coupled receptor superfamily: BLT1 and BLT2. BLT1 displays high affinity for LTB4 and is highly expressed in leukocytes including granulocytes, macrophages, mast cells, dendritic cells and effector T cells3 and is expressed to much lower levels in spleen, thymus, heart, skeletal muscle brain and liver2-4. BLT2 on the other hand is a low affinity receptor which does not display selectivity towards LTB45. Its expression is much more ubiquitous than that of BLT1. It is expressed in most human tissues, with the highest expression being in spleen, liver, ovary, and leukocytes2,5-8. The two receptors could couple and activate different G-proteins, depending on the cell type and the cellular events activating the receptors2. However, activation of BLT1 ususally correlates with increasing intracellular concentrations of Ca2+.The LTB4/BLT1 system is involved in many allergic reactions as well as asthma induced as an allergic response, where it plays a significant role in recruiting neutrophils and effector T cells into lungs, as part of an inflammatory response induced by allergens1.Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of human BLT1. Anti-Human BLT1 (extracellular) antibody (#AG1223) can be used for Western blot analysisand indirect flow cytometry applications. It has been designed to recognize BLT1 from human samples only.
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