TLK1 Antibody (aa730-779)

分子量：
86700 Da
细胞定位：
Antigen Cellular Localization:Nucleus
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Yamakawa A.,et al.Gene 202:193-201(1997).Sillje H.H.W.,et al.EMBO J. 18:5691-5702(1999).Cabaniols J.-P.,et al.Mol. Biol. Cell 10:4033-4041(1999).Nagase T.,et al.DNA Res. 2:167-174(1995).Nakajima D.,et al.DNA Res. 9:99-106(2002).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality TLK1 antibody (aa730-779).
功能：
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
总结：
Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.
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