TLK1 Antibody (aa730-779) | LBP85378 | Leading Biology

商品分类：多克隆抗体

产品概述：Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

靶点/蛋白：TLK1 Antibody detects endogenous levels of total TLK1 protein.

来源：Rabbit

参考文献：Yamakawa A.,et al.Gene 202:193-201(1997).Sillje H.H.W.,et al.EMBO J. 18:5691-5702(1999).Cabaniols J.-P.,et al.Mol. Biol. Cell 10:4033-4041(1999).Nagase T.,et al.DNA Res. 2:167-174(1995).Nakajima D.,et al.DNA Res. 9:99-106(2002).

特异性：Human, Mouse

别名：TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK

应用：ELISA (1:5000), IF (1:100 - 1:500), IHC-P (20 μg/ml),

简单描述：Rabbit Polyclonal TLK1 Antibody (aa730-779). Validated for use in IHC-P, IF, E.

详情：FunctionRapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S- phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.Cellular_LocationNucleusTissue_LocationWidely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined.

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