CD71 / Transferrin Receptor Antibody (aa15-64)

分子量：
85kDa
细胞定位：
Antigen Cellular Localization:Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Schneider C.,et al.Nature 311:675-678(1984).McClelland A.,et al.Cell 39:267-274(1984).Evans P.,et al.Gene 199:123-131(1997).Wheeler D.L.,et al.Thesis (1999), University of Iowa, United States.Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality CD71 / Transferrin Receptor antibody (aa15-64).
功能：
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
总结：
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
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