SFN / Stratifin / 14-3-3 Sigma Antibody (aa120-170)

分子量：
28kDa
细胞定位：
Antigen Cellular Localization:Cytoplasm. Nucleus. Secreted. Note=May be secreted by a non-classical secretory pathway
形式：
Liquid
参考文献：
Prasad G.L.,et al.Cell Growth Differ. 3:507-513(1992).Leffers H.,et al.J. Mol. Biol. 231:982-998(1993).Hermeking H.,et al.Mol. Cell 1:3-11(1997).Halleck A.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.Gregory S.G.,et al.Nature 441:315-321(2006).
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality SFN / Stratifin / 14-3-3 Sigma antibody (aa120-170).
功能：
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
总结：
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.
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