CD86 (Dendritic Cells Maturation Marker) Antibody

分子量：
70kDa
细胞定位：
Antigen Cellular Localization:Cell membrane; Single-pass type I membrane protein
形式：
Liquid. In PBS containing 0.02% sodium azide.
参考文献：
Engel P et. al. Blood. 1994;84(5):1402-7.Caux C et. al. J Exp Med. 1994;180(5):1841-7. Mauri D et. al. J Immunol. 1995;155(1):118-27.Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995).Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997)
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality CD86 (Dendritic Cells Maturation Marker) antibody.
功能：
Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.
总结：
Recognizes a protein of 70kDa, which is identified as CD86 (HLDA V; WS Code BP BP072. HLDA V; WS Code A A109. HLDA VI; WS Code BP 95. HLDA VI; WS Code B CD86.9). CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.
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