CD86 (Dendritic Cells Maturation Marker) Antibody - With BSA and Azide | LM18060 | Leading Biology

商品分类：单克隆抗体

产品概述：Recognizes a protein of 70kDa, which is identified as CD86. CD86 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily of cell surface receptors. It is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes. CD86 expression is rapidly upregulated by B cell specific stimuli with peak expression at 18 to 42 hours after stimulation. CD86, along with CD80/B71, is an important accessory molecule in T cell co-stimulation via its interaction with CD28 and CD152/CTLA4. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response. It is also found on malignant Hodgkin and Reed Sternberg (HRS) cells in Hodgkin's disease.

来源：Mouse

特异性：Human, Mouse, Rat

别名：T-lymphocyte activation antigen CD86, Activation B7-2 antigen, B70, BU63, CTLA-4 counter-receptor B7.2, FUN-1, CD86, CD86, CD28LG2

简单描述：Mouse Monoclonal CD86 (Dendritic Cells Maturation Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, IF, FC. Clone: C86/1146.

详情：FunctionReceptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.Cellular_LocationCell membrane; Single-pass type I membrane proteinTissue_LocationExpressed by activated B-lymphocytes and monocytes

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企业 QQ：3212874516、3198592576

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