Lamin B Receptor Antibody Receptor

分子量：
70703 Da
细胞定位：
Antigen Cellular Localization:Nucleus inner membrane; Multi-pass membrane protein
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Gruenbaum, Y., et al. Review: nuclear lamins
2. Ye, Q. and H.J. Worman. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J. Biol. Chem. 269: 11306
3. Oberhammer, F.A., et al. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126: 827
4. Rao, L., et al. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135: 1441

产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Lamin B Receptor antibody Receptor.
功能：
Anchors the lamina and the heterochromatin to the inner nuclear membrane.
总结：
Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).
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