Lamin B Receptor Antibody Receptor | LM17238 | Leading Biology

商品分类：单克隆抗体

产品概述：Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).

靶点/蛋白：A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. Gruenbaum, Y., et al. Review: nuclear lamins
2. Ye, Q. and H.J. Worman. Primary structure analysis and lamin B and DNA binding of human LBR, an integral protein of the nuclear envelope inner membrane. J. Biol. Chem. 269: 11306
3. Oberhammer, F.A., et al. Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase. J. Cell Biol. 126: 827
4. Rao, L., et al. Lamin proteolysis facilitates nuclear events during apoptosis. J. Cell Biol. 135: 1441


特异性：Human, Rat

别名：Lamin-B receptor, Integral nuclear envelope inner membrane protein, LMN2R, LBR

应用：WB~~1:5000

简单描述：Rabbit Monoclonal Lamin B Receptor Antibody Receptor. Validated for use in WB, IF. Clone: E398L.

详情：FunctionAnchors the lamina and the heterochromatin to the inner nuclear membrane.Cellular_LocationNucleus inner membrane; Multi-pass membrane protein

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层