Crystallin Alpha B Antibody Crystallin

分子量：
20159 Da
细胞定位：
Antigen Cellular Localization:Cytoplasm. Nucleus. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles
形式：
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献：
1. Dubin RA, et al. Genomics 7(4):594-601, 1990
2. Iwaki A, et al. Neurosci Lett 140(1):89-92, 1992
3. Kato K, et al. J Neurochem 76(3):730-6, 2001
4. Fujii N, et al. Biochim Biophys Acta 204(2):157-63, 1994

产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality Crystallin Alpha B antibody Crystallin.
功能：
May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.
总结：
Alpha B Crystallin, first identified as a structural component of the vertebrate eye lens, is expressed at high levels in lens and at lower levels in a number of other tissues, most notably cardiac and skeletal muscle, kidney, and brain (1). It is a major protein component of Rosenthal fibers, which massively accumulate in the brains of patients suffering from Alexander's disease (2). The major phosphorylation site of Alpha B Crystallin in brains of patients with Alexander's disease or Alzheimer's disease as well as in aged controls is Serine 59 (3). Racemization, isomerization, and oxidation of Alpha B Crystallin are said to occur spontaneously in the aging process (4).
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