Cytochrome c - pigeon (88-104)

• 纯度 = 99.31%

氨基酸序列为H-Lys-Ala-Glu-Arg-Ala-Asp-Leu-Ile-Ala-Tyr-Leu-Lys-Gln-Ala-Thr-Ala-Lys-OH。

I-E^k-限制性T细胞对细胞色素C - 鸽子（pcyt c）COOH末端88-104[1]多肽的应答是特异的。

T细胞激活所需的pcyt C多肽的Z小长度为COOH末端序列含有的残基95-104。然而，残基95的NH2末端加入额外的残基可增加肽的抗原效力，效应是由pcyt c 88-104引起的。

取代细胞色素C多肽95到104之间的任何一个残基可以改变细胞色素C多肽对至少一种杂交瘤的抗原性。

Figure1. Structure of Cytochrome c

Figure2. Formula of Cytochrome c - pigeon (88-104)

C₈₄H₁₄₄N₂₄O₂₅

参考文献：

1. Schwartz, R. H. 1985. T lymphocyte recognition of antigen in association with gene products of the MHC. Annu. Rev. Immunol. 3:237.

2. Bhayani, H., F. R. Carbone, and Y. Paterson. 1988. The activation of pigeon cytochrome c-specific T cell hybridomas by antigenic peptides is influenced by non-native sequences at the amino terminus of the determinant. J. Immunol. 141:377.

3. Bhayani, H., Y. Paterson. 1989. Analysis of peptide binding patterns in different major histocompatibility complex/t cell receptor complexes using pigeon cytochrome c-specific t cell hybridomas.