DiscoveryProbe™ MAPK Signaling Pathway Compounds Panel

Compound Panel Contents

Catalog No.	Product Name	Summary	Targets	CAS Number	Smiles
A3943	XMD8-92	BMK1/ERK5 inhibitor,highly selective	MAPK Signaling|ERK	1234480-50-2	CCOC1=C(C=CC(=C1)N2CCC(CC2)O)NC3=NC=C4C(=N3)N(C5=CC=CC=C5C(=O)N4C)C
A3519	JNK-IN-7	Selective JNK inhibitor	MAPK Signaling|JNK	1408064-71-0	CN(C)CC=CC(=O)NC1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CN=CC=C4
A1947	MEK162 (ARRY-162, ARRY-438162)	MEK1/2 inhibitor,potent and selective	MAPK Signaling|MEK1/2	606143-89-9	CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
A3004	Vemurafenib (PLX4032, RG7204)	BRAF kinase inhibitor	MAPK Signaling|MEK1/2	918504-65-1	CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=NC=C(C=C23)C4=CC=C(C=C4)Cl)F
A3805	SCH772984	Novel ERK1 and ERK2 inhibitor	MAPK Signaling|MEK1/2	942183-80-4	C1CN(CC1C(=O)NC2=CC3=C(C=C2)NN=C3C4=CC=NC=C4)CC(=O)N5CCN(CC5)C6=CC=C(C=C6)C7=NC=CC=N7
A5801	BIX 02189	Selective MEK5 inhibitor	MAPK Signaling|MEK1/2	1094614-85-3	CN(C)CC1=CC(=CC=C1)NC(=C2C3=C(C=C(C=C3)C(=O)N(C)C)NC2=O)C4=CC=CC=C4
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Advantages

• Available in stock with overnight delivery and free shipping over $500
• Cost-effective and competitive price to save your findings
• Potent, selective and cell-permeable in inhibiting or activating target molecules
• Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
• Detailed files describing potency, selectivity and applications etc.
• Supported by published data from top peer-reviewed journals
• Guaranteed high quality with NMR and HPLC validation

产品描述
A wide range of well-characterized bioactive molecules that covers various targets on the MAPK signaling pathway, including MEK1/2, p38 and Raf etc. Facilitate your research towards the insights of cell proliferation, differentiation, apoptosis and motility etc. Applicable in cellular assays, animal models and drug screenings etc.
References
1. Plotnikov A, Zehorai E, Procaccia S, Seger R. The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation. Biochim Biophys Acta. 2011 Sep;1813(9):1619-33. 
Abstract 
The MAPK cascades are central signaling pathways that regulate a wide variety of stimulated cellular processes, including proliferation, differentiation, apoptosis and stress response. In this review, we briefly cover the composition of the MAPK cascades, as well as their physiological and pathological functions. The nuclear translocation of signaling components may emerge as an important regulatory layer in the induction of cellular processes, and therefore, may serve as targets for therapeutic intervention in signaling-related diseases such as cancer and diabetes.