Compound Panel Contents Catalog No. | Product Name | Summary | Targets | CAS Number | Smiles |
A8455 | Nilvadipine | Potent calcium channel blocker | Membrane Transporter/Ion Channel|Calcium Channel | 75530-68-6 | CC1=C(C(C(=C(N1)C#N)C(=O)OC)C2=CC(=CC=C2)[N+](=O)[O-])C(=O)OC(C)C |
A8351 | VX-809 | CFTR corrector | Membrane Transporter/Ion Channel|CFTR | 936727-05-8 | CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O |
A1855 | Bumetanide | Inhibitor of Na+/K+/Cl- cotransporter | Membrane Transporter/Ion Channel|NKCC | 28395-03-1 | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 |
A3100 | (+)-MK 801 | Potent NMDA antagonist | Membrane Transporter/Ion Channel|NMDA Receptor | 70449-94-4 | C[C@]1(N2)C3=C(C=CC=C3)C[C@@H]2C4=C1C=CC=C4 |
A3532 | KN-93 | CaMKII inhibitor,selective and competitive | Membrane Transporter/Ion Channel|P2X purinergic receptor | 139298-40-1 | CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2N(CCO)S(=O)(=O)C3=CC=C(C=C3)OC |
B7659 | Psora 4 | Potent KV1.3 channel blocker | Membrane Transporter/Ion Channel|Potassium Channel | 724709-68-6 | O=C1OC2=C(C=C1)C(OCCCCC3=CC=CC=C3)=C4C(OC=C4)=C2 |
B4798 | Procainamide HCl | Na+ channel blocker; DNA methyltransferase 1 inhibitor | Membrane Transporter/Ion Channel|Sodium Channel | 614-39-1 | CCN(CC)CCNC(=O)C1=CC=C(C=C1)N.Cl |
A8519 | SB705498 | TRPV1 antagonist,potent and selective | Membrane Transporter/Ion Channel|TRPV1 | 501951-42-4 | C1CN(CC1NC(=O)NC2=CC=CC=C2Br)C3=NC=C(C=C3)C(F)(F)F |
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Advantages - Available in stock with overnight delivery and free shipping over $500
- Cost-effective and competitive price to save your findings
- Potent, selective and cell-permeable in inhibiting or activating target molecules
- Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.)
- Detailed files describing potency, selectivity and applications etc.
- Supported by published data from top peer-reviewed journals
- Guaranteed high quality with NMR and HPLC validation
产品描述A wide range of well-characterized bioactive molecules that covers various targets related to membrane transporter/ion channel, including ATPase, calcium channel and CFTR etc. Facilitate your research towards the insights of heart diseases, cystic fibrosis and immune disorders etc. Applicable in cellular assays, animal models and drug screenings etc.
References1. Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29.
Abstract
Ca2+ is a highly versatile intracellular signal that operates over a wide temporal range to regulate many different cellular processes. Rapid highly localized Ca2+ spikes regulate fast responses, whereas slower responses are controlled by repetitive global Ca2+ transients or intracellular Ca2+ waves. Ca2+ has a direct role in controlling the expression patterns of its signalling systems that are constantly being remodelled in both health and disease.
2. Sajja RK, Cucullo L. Altered glycaemia differentially modulates efflux transporter expression and activity in hCMEC/D3 cell line. Neurosci Lett. 2015 Jun 26;598:59-65.
Abstract
The impact of diabetes on BBB efflux transporters is less understood. In this study, we examined the effects of single or repeated episodes of hypo-and hyperglycemia on major BBB efflux transporters expression/function in human cerebromicrovascular endothelial cell line (hCMEC/D3). this study suggests a differential impact of altered glycemic conditions on major BBB drug efflux transporters expression/function, sensitive to the length of exposure (acute vs. repeated), with an implication for altered CNS drug disposition in diabetic population.
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