A2A Adenosine Receptor Antibody | LBP77056 | Leading Biology

商品分类：多克隆抗体

产品概述：Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions of many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine Receptor (A1AR), A2A-Adenosine Receptor (A2AAR), A2B-Adenosine Receptor (A2BAR), and A3-Adenosine Receptor (A3AR). All are integral membrane proteins and are members of the G protein-coupled receptor superfamily, which share a common structure of seven putative transmembrane domains, an extracellular NH2 terminus, cytoplasmic COOH terminus, and a third intracellular loop important for binding G proteins.1-3 The adenosine receptors can be distinguished on the basis of their differential selectivity for adenosine analogs.1-3Adenosine receptors control neurotransmitter release through the facilitatory A2AAR and the inhibitory A1AR.4 A2AAR and A1AR are the major adenosine receptor subtypes expressed in the central nervous system (CNS). A2AAR is mainly expressed in the striatum on GABAergic striatopallidal neurons, while A1AR is widely distributed throughout the CNS.5,6A2AAR was suggested to play a critical role in attenuation of systemic inflammatory responses and prevention of extensive tissue damage.7 It was suggested that extracellular adenosine that accumulates in inflamed and damaged tissue may activate the A2AAR expressed in immune cells leading to termination/inhibition of the immune response.7 It was further suggested that this same mechanism may protect tumors from antitumor T cells through an immunosuppressive signal generated by the activation of A2AAR on T cells by extracellular adenosine produced from hypoxic cancerous tissues.8 Abgent is pleased to introduce a new antibody directed against an epitope of mouse A2A-Adenosine receptor. Anti-A2A Adenosine Receptor antibody (#AG1386) can be used in western blot and immunohistochemical applications, and has been designed to recognize A2AAR from human, rat, and mouse samples.

靶点/蛋白：Peptide (C)RQLKQMESQPLPGER, ?corresponding to amino acid residues 201-215 of? mouse A2A Adenosine receptor (Accession Q60613). 3rd intracellular loop.

来源：Rabbit

存储溶液：Affinity purified antibody, lyophilized powder

参考文献：1. Okusa, M.D. (2002) Am. J. Physiol. Renal. Physiol. 282, F10.2. Fredholm, B.B. et al. (2001) Pharmacol. Rev. 53, 527.3. Nakata, H. (1989) J. Biol. Chem. 264, 16545.4. Cunha, R.A. (2001) Neurochem. Int. 38, 107.5. Fredholm, B.B. et al. (2000) Naunyn-Schmiedebergs Arch. Pharmacol. 362, 364.6. Canals, M. et al. (2005) J. Neurochem. 92, 337.7. Ohta, A. and Sitkovsky, M. (2001) Nature 414, 916.8. Ohta, A. et al. (2006) Proc. Natl. Acad. Sci. 103, 13132.

特异性：Human, Mouse, Rat

别名：Adenosine receptor A2a, Adora2a

应用：WB~~1:200-1:2000

简单描述：Rabbit Polyclonal A2A Adenosine Receptor Antibody. Validated for use in WB, IHC.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层