FAIM2 / LIFEGUARD Antibody (N-Terminus) | LBP72891 | Leading Biology

商品分类：多克隆抗体

产品概述：Antiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.

靶点/蛋白：16 amino acid peptide from near the amino terminus of human LFG.

来源：Rabbit

参考文献：Somia N.V.,et al.Proc. Natl. Acad. Sci. U.S.A. 96:12667-12672(1999).Nagase T.,et al.DNA Res. 6:63-70(1999).Ota T.,et al.Nat. Genet. 36:40-45(2004).Scherer S.E.,et al.Nature 440:346-351(2006).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

特异性：Human, Mouse, Rat

别名：Protein lifeguard 2, Fas apoptotic inhibitory molecule 2, Neural membrane protein 35, Transmembrane BAX inhibitor motif-containing protein 2, FAIM2, KIAA0950, LFG, LFG2, NMP35, TMBIM2

应用：IHC-P (5 μg/ml)

简单描述：Rabbit Polyclonal FAIM2 / LIFEGUARD Antibody (N-Terminus). Validated for use in WB, IHC-P.

详情：FunctionAntiapoptotic protein which protects cells uniquely from Fas-induced apoptosis. Regulates Fas-mediated apoptosis in neurons by interfering with caspase-8 activation. May play a role in cerebellar development by affecting cerebellar size, internal granular layer (IGL) thickness, and Purkinje cell (PC) development.Cellular_LocationCell membrane; Multi-pass membrane protein. Membrane raft. Cell junction, synapse, postsynaptic cell membraneTissue_LocationHighly expressed in breast carcinoma tissues. Enhanced expression correlates with the grade of the tumor (grade II/grade III) in primary breast tumors (at protein level). Widely expressed. Expressed at high levels in the brain especially in the hippocampus.

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企业 QQ：3212874516、3198592576

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