商品分类:多克隆抗体
产品概述:Interferons are widely used therapeutic agents because of their anti tumor and antiviral effects and because of their modulatory effects on the immune system (Biron, 2001; Kirkwood, 2002). These cytokines produce their effects by binding to the Type 1 Interferon-α Receptor (IFNAR1). Down regulation of this receptor plays a key role in determining the magnitude and duration of cytokine signaling. This down regulation is thought to be influenced by phosphorylation of Serine 535 and 539 in the IFNAR1 (Kumar et al., 2003).
靶点/蛋白:Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser535/539 conjugated to KLH.
来源:Rabbit
存储溶液:Prepared from rabbit serum by affinity purification via sequentialchromatography on phospho- and dephosphopeptide affinity columns.
参考文献:Biron CA (2001) Interferons alpha and beta as immune regulators--a new look. Immunity 14:661-664.Kirkwood J (2002) Cancer immunotherapy: the interferon-alpha experience. Semin Oncol 29:18-26.Kumar KG, Tang W, Ravindranath AK, Clark WA, Croze E, Fuchs SY (2003) SCF(HOS) ubiquitin ligase mediates theligand-induced down-regulation of the interferon-alpha receptor. EMBO J 22:5480-5490.K. G. Suresh Kumar, John J. Krolewski, and Serge Y. Fuchs (2004) Phosphorylation and Specific Ubiquitin AcceptorSites Are Required for Ubiquitination and Degradation of the IFNAR1 Subunit of Type I Interferon Receptor. J.Biol. Chem., Nov 2004; 279: 46614 - 46620.
特异性:Rat
别名:Interferon alpha/beta receptor 1, IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1, IFNAR1, IFNAR
应用:WB~~ 1:1000
简单描述:Rabbit polyclonal Phospho-Ser535,539 Interferon-α Receptor, Type I, Subunit I Antibody. Validated for use in WB.
生物商城:http://www.annoron.com
办公电话:010-56256916
官方售后:400-965-8633
企业 QQ:3212874516、3198592576
地 址:北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示:不可用于临床ZL。