Phospho-M ERBB2(Y1140) Antibody | LBP62882 | Leading Biology

商品分类：多克隆抗体

产品概述：This gene encodes a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. This proteinhas no ligand binding domain of its own and therefore cannot bindgrowth factors. However, it does bind tightly to other ligand-boundEGF receptor family members to form a heterodimer, stabilizingligand binding and enhancing kinase-mediated activation ofdownstream signalling pathways, such as those involvingmitogen-activated protein kinase and phosphatidylinositol-3 kinase.Allelic variations at amino acid positions 654 and 655 of isoform a(positions 624 and 625 of isoform b) have been reported, with themost common allele, Ile654/Ile655, shown here. Amplification and/oroverexpression of this gene has been reported in numerous cancers,including breast and ovarian tumors. Alternative splicing resultsin several additional transcript variants, some encoding differentisoforms and others that have not been fully characterized.

靶点/蛋白：This mouse ERBB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1140 of mouse ERBB2.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Cabodi, S., et al. FASEB J. 24(10):3796-3808(2010)Johnson, E., et al. J. Biol. Chem. 285(38):29491-29501(2010)Huck, L., et al. Proc. Natl. Acad. Sci. U.S.A. 107(35):15559-15564(2010)Chuang, T.D., et al. J. Biol. Chem. 285(31):23598-23606(2010)Simeone, L., et al. J. Neurosci. 30(19):6620-6634(2010)

特异性：Human, Mouse

别名：Receptor tyrosine-protein kinase erbB-2, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, p185erbB2, CD340, Erbb2, Kiaa3023, Neu

应用：WB~~1:1000DB~~1:500

简单描述：Rabbit Polyclonal Phospho-M ERBB2(Y1140) Antibody. Validated for use in DB, WB, E.

详情：FunctionProtein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity).Cellular_LocationCell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. NucleusTissue_LocationExpressed predominantly in uterine epithelial cells. In the muscle, expression localizes to the synaptic sites of muscle fibers

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企业 QQ：3212874516、3198592576

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