INHA / Inhibin Alpha Antibody | LBP61931 | Leading Biology

商品分类：多克隆抗体

产品概述：Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

来源：Rabbit

参考文献：Mayo K.E.,et al.Proc. Natl. Acad. Sci. U.S.A. 83:5849-5853(1986).Stewart A.G.,et al.FEBS Lett. 206:329-334(1986).Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004).Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

特异性：Human

别名：Inhibin alpha chain, INHA

应用：IHC-P (1:50)

简单描述：Rabbit Polyclonal INHA / Inhibin Alpha Antibody. Validated for use in IHC-P.

详情：FunctionInhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.Cellular_LocationSecreted.Tissue_LocationOriginally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female

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