Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - Without BSA and Azide | LM15767 | Leading Biology

商品分类：单克隆抗体

产品概述：This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

来源：Mouse

存储溶液：200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

参考文献：Pezzella F et. al.. American Journal of Pathology, 1990, 137(2):225-32

特异性：Human

别名：Apoptosis regulator Bcl-2, BCL2

简单描述：Mouse Monoclonal Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - Without BSA and Azide. Validated for use in WB, IHC-P, IF, FC. Clone: SPM530.

详情：FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).Cellular_LocationMitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane proteinTissue_LocationExpressed in a variety of tissues.

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官方售后：400-965-8633

企业 QQ：3212874516、3198592576

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