Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide | LM15762 | Leading Biology

商品分类：单克隆抗体

产品概述：This antibody recognizes a protein of 25-26kDa, identified as the bcl-2?lpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2?lpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2?lpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

靶点/蛋白：A synthetic peptide, aa41-54 (GAAPAPGIFSSQPG-Cys) of human Bcl-2 protein.

来源：Mouse

存储溶液：0.5 ml at 200ug/ml with BSA and azide

参考文献：1. Wolter KG, et. al. Journal of Cell Biology, 1997, 139(5):1281-92.

特异性：Human, Pig, Monkey

别名：Apoptosis regulator Bcl-2, BCL2

简单描述：Mouse Monoclonal Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide. Validated for use in WB, IHC, IF, FC, IP, E. Clone: 8C8.

详情：FunctionSuppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).Cellular_LocationMitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane proteinTissue_LocationExpressed in a variety of tissues.

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层