Cyclin B1 (G2- & M-phase Cyclin) Antibody | LM10601 | Leading Biology

商品分类：单克隆抗体

产品概述：It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.

来源：Mouse

参考文献：Galaktionov, K. and Beach D. 1991. Specific activation of Cdc25 tyrosine phosphatases by B type cyclins: Evidence for multiple roles of mitotic cyclins. Cell 67: 1181-1194

特异性：Human, Mouse

别名：G2/mitotic-specific cyclin-B1, CCNB1, CCNB

简单描述：Mouse Monoclonal Cyclin B1 (G2- & M-phase Cyclin) Antibody. Validated for use in IHC, IF, FC. Clone: CCNB1/1098.

详情：FunctionEssential for the control of the cell cycle at the G2/M (mitosis) transition.Cellular_LocationCytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层