Recombinant Human IL-21，重组人IL-21_详细资料

产品信息

数量：大量规格： 2µg

规格：产品价格：￥0

规格： 2µg 产品价格：￥0

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Recombinant Human IL-21
产品编号:
200-21
别名:
none.
描述:
IL-21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells, stimulation (in conjuction) with IL-4 of IgG production, and induction of apoptotic effects in naïve B-cells and stimulated B-cells in the absence of T-cell signaling. Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 exerts its effect through binding to a specific type I cytokine receptor, IL-21R, which also contains the γ chain (γc) found in other cytokine receptors including IL-2, IL-4, IL-7, IL-9 and IL-15. The IL-21/IL-21R interaction triggers a cascade of events which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.
氨基酸序列:
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ HLSSRTHGSE DS
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
Assay #1:Determined by its ability to proliferate activated B cells.

Assay #2:Determined by its ability to induce human CD40L-activated naïve B cells to undergo Ig isotype switching to IgG, using an IL-21 concentration of 50 ng/ml. Maximal activity was achieved after approximately five cell divisions.
_{Avery, D.T. et. al. (2008) J. Immunol. 181, 1767-1779.}

温馨提示：不可用于临床ZL。

规格：		产品价格：	￥0
规格：	2µg	产品价格：	￥0

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