Recombinant Human IL-13 Variant，重组人IL-13变种_详细资料

产品信息 数量：大量规格： 2µg 规格：产品价格：￥0 规格： 2µg 产品价格：￥0 本公司代理多种品Pai耗材, 如需订购请联系24小时为您服务： 公司电话：021-61507986 手机：15601775891 Q Q：1597844312 Recombinant Human IL-13 Variant 产品编号: 200-13A 别名: none. 描述: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112. 氨基酸序列: MSPGPVPPST ALRELIEELV NITQNQKAPL CNGSMVWSIN LTAGMYCAAL ESLINVSGCS AIEKTQRMLS GFCPHKVSAG QFSSLHVRDT KIEVAQFVKD LLLHLKKLFR EGQFN 来源: E.coli 纯度: Greater than 98% by SDS-PAGE gel and HPLC analyses. 生物活性: This IL-13 analog shows a two fold increase, relative to wild type IL-13, in bioactivity as measured by the in-vitro dose dependent activation of STAT6 and IL-13 dependent gene induction in transfected A201.1 cells. This analog has also been shown to exhibit increased in vivo activity compared to wild type IL-13, as measured by the induction of airway hyper-responsiveness. 温馨提示：不可用于临床ZL。

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规格：	2µg	产品价格：	￥0

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Recombinant Human IL-13 Variant，重组人IL-13变种

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