AC220 (Quizartinib)、CAS号: 950769-58-1

AC220 (Quizartinib) 的产品信息
英文名称：AC220 (Quizartinib)，请联系客服QQ：1443869017获知AC220 (Quizartinib)的库存和报价。
  上海赛鑫生物技术有限公司 供应美国原装进口：AC220 (Quizartinib)
所属分类：现货> -20摄氏度低温储备> Flt YZ剂 >> AC220 (Quizartinib)
 别名：N/A
分子式：C₂₉H₃₂N₆O₄S
分子量：560.67
CAS号：950769-58-1
物质化学性质：
 生物活性
AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. AC220 exhibits low nanomolar potency in biochemical and cellular assays and exceptional kinase selectivity, and in animal models is efficacious at doses as low as 1 mg/kg given orally once daily. The data reveal that the combination of excellent potency, selectivity, and pharmacokinetic properties is unique to AC220, which therefore is the first candidate with a profile that matches the characteristics desirable for a clinical FLT3 inhibitor. ^[1][2] 
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