Product Overview
Stemgent™ Purified Rabbit anti-Mouse/Human Sox2 Antibody was screened on human and mouse embryonic stem (ES) cells using immunocytochemistry (ICC) and intracellular staining by flow cytometry (FC) and selected as the best Sox2 antibody available for researchers needing to demonstrate pluripotency. Sox2, also known as SRY (sex determining region Y)-box 2, is a transcription factor essential for maintaining self-renewal of undifferentiated ES cells and is one of the key transcription factors used to reprogram mouse and human fibroblasts to a pluripotent state1-3.
References
- David J. Rodda, Joon-Lin Chew, Leng-Hiong Lim, Yuin-Han Loh, Bei Wang, Huck-Hui Ng and Paul Robson. (2005) Transcriptional Regulation of Nanog by OCT4 and SOX2. J. Biol. Chem. 280:24731-24737.
- Laurie A. Boyer, Tong Ihn Lee, Megan F. Cole, Sarah E. Johnstone, Stuart S. Levine, Jacob P. Zucker, Matthew G. Guenther, Roshan M. Kumar, Heather L. Murray, Richard G. Jenner, David K. Gifford, Douglas A. Melton, Rudolf Jaenisch, and Richard A. Young. (2005) Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 23:122(6):947-956.
- Helen Fong, Kristi A. Hohenstein, Peter J. Donovan. (2008) Regulation of Self-Renewal and Pluripotency by Sox2 in Human Embryonic Stem Cells. Stem Cells 26:1931–1938.
- Kazutoshi Takahashi and Shinya Yamanaka. (2006) Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors. Cell 126:663–676.
- Kazutoshi Takahashi, Koji Tanabe, Mari Ohnuki, Megumi Narita, Tomoko Ichisaka, Kiichiro Tomoda, Shinya Yamanaka. (2007) Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors. Cell 131:861–872.
- In-Hyun Park, Natasha Arora, Hongguang Huo, Nimet Maherali, Tim Ahfeldt, Akiko Shimamura, M. William Lensch, Chad Cowan, Konrad Hochedlinger, George Q. Daley. (2008) Disease-Specific Induced Pluripotent Stem Cells. Cell 134:1–10.