Product Overview
Affinity Purified anti-Mouse/Human Nanog was screened on human and mouse ES cells using ICC and selected as the best Nanog antibody available for researchers needing to demonstrate pluripotency. Nanog is a member of the homeobox family of DNA binding transcription factors and has been shown to maintain embryonic stem (ES) cell self-renewal independently of leukemia inhibitory factor (LIF)/Stat31,2. Nanog mRNA is present in pluripotent mouse and human cell lines, and absent from differentiated cells. Functionally, Nanog works together with other key pluripotent factors (Oct4, Sox2, and Lin28) to reprogram human fibroblasts and generate induced pluripotent stem (iPS) cells3. These key factors form a regulatory network to support or limit each other's expression level, which maintains the properties of ES cells4,5.
References
- Kaoru Mitsui, Yoshimi Tokuzawa, Hiroaki Itoh, Kohichi Segawa, Mirei Murakami, Kazutoshi Takahashi, Masayoshi Maruyama, Mitsuyo Maeda, and Shinya Yamanaka. (2003) The Homeoprotein Nanog Is Required for Maintenance of Pluripotency in Mouse Epiblast and ES Cells. Cell 113:631-642.
- Ian Chambers , Douglas Colby, Morag Robertson, Jennifer Nichols, Sonia Lee, Susan Tweedie and Austin Smith (2003) Functional Expression Cloning of Nanog, a Pluripotency Sustaining Factor in Embryonic Stem Cells. Cell 113(5):643-655.
- Junying Yu, Maxim A. Vodyanik, Kim Smuga-Otto, Jessica Antosiewicz-Bourget, Jennifer L. Frane, Shulan Tian, Jeff Nie, Gudrun A. Jonsdottir, Victor Ruotti, Ron Stewart, Igor I. Slukvin, James A. Thomson. (2007) Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science (318) 21:1917-1920.
- Guangjin Pan and James A Thomson (2007) Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 17:42-49.
- Jonghwan Kim, Jianlin Chu, Xiaohua Shen, Jianglong Wang, Stuart H. Orkin. (2008) An Extended Transcriptional Network for Pluripotency of Embryonic Stem Cells. Cell 132: 1049-1061.