MSA肌肉特异性肌动蛋白（鼠单克隆抗体）Actin,Muscle Sp...

MSA肌肉特异性肌动蛋白（鼠单克隆抗体）Actin,Muscle Specific

广州健仑生物科技有限公司

肌动蛋白是一种中等大小的蛋白质， 由375个氨基酸残基组成， 并且是由一个大的、高度保守的基因编码。 以两种形式存在， 即单体和多聚体。单体的肌动蛋白是由一条多肽链构成的球形分子， 又称球状肌动蛋白(globular actin, G-actin),外形类似花生果。肌动蛋白的多聚体形成肌动蛋白丝， 称为纤维状肌动蛋白(fibros actin, F-actin)。在电子显微镜下， F-肌动蛋白呈双股螺旋状， 直径为8nm, 螺旋间的距离为37nm。肌动蛋白是真核细胞中Z丰富的蛋白质。在肌细胞中， 肌动蛋白占总蛋白的10%, 即使在非肌细胞中， 肌动蛋白也占细胞总蛋白的1～5%。

MSA可以识别骨骼肌、心肌和平滑肌的α肌动蛋白和γ肌动蛋白，用以标记骨骼肌、心肌和平滑肌及其来源的肿瘤。非肌肉细胞如血管内皮细胞和结缔组织不与之反应。因此，非肌源性肿瘤如上皮肿瘤、黑色素瘤、淋巴瘤等对于该抗体呈阴性表达。

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【产品介绍】

细胞定位：细胞浆

克隆号：HHF35

同型：IgG1/K

适用组织：石蜡/冰冻

阳性对照：阑尾

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

MSA肌肉特异性肌动蛋白（鼠单克隆抗体）Actin,Muscle Specific

临床表现
普通型起病一般缓慢，有腹部不适，大便稀薄，有时腹泻，每日数次，有时亦可便秘。腹泻时大便略有脓血痢疾样。如病变发展，痢疾样大便可增至每日10～15次或以上，伴有里急后重，腹痛加剧和腹胀。回盲肠、横结肠，尤其是直肠部可有压痛，有时象溃疡病或阑尾炎。全身症状一般较轻微，同细菌性痢疾迥然不同。粪检可有少量或多量滋养体，大便有抗原抗体腥臭。
阿米巴肝脓肿症状的出现，约在肠阿米巴数月、数年，甚至十数年之后，亦有从未患过肠阿米巴病的。起病大多缓渐，以长期不规则发热与夜间盗汗等消耗性症状为主，在发病前一周至数年间可有类似痢疾样发作史。实验室检查疾病早期白细胞总数有显著增加，在15，000～35，000之间，中性粒细胞可超出80%。粪便内如能找到滋养体或包囊，对诊断有助。通过诊断性穿刺，如能抽出典型巧克力样脓液并在其中找到夏一雷结晶及组织残余，诊断即可确立，如再能检得阿米巴滋养体，诊断更为确切。
并发症
有肠内、肠外两大类。肠外并发症将在肝阿米巴病及其他少见肠外阿米巴病中叙述。以下系指阿米巴病的肠内并发症。
1．肠穿孔：此系肠阿米巴病威胁生命Z大的并发症。穿孔可因肠壁病变使肠腔内容物渗入腹腔酿成局限性或弥漫性腹膜炎或腹腔脓肿，亦偶因直肠镜检查时外伤性穿破而造成。弥漫性腹膜炎较多见，预后不良。肠壁深溃疡大多引起慢性穿孔，部位多在盲肠、阑尾。外伤性穿孔多见于直肠。
2．肠出血深部溃疡：可以侵蚀血管，引起大小不等的肠出血，大出血威胁生命，必须积极抢救并给予抗阿米巴药物ZL。
3．阑尾炎：阿米巴可侵袭阑尾，临床上表现与一般阑尾炎相似的症状，偶可成为肠阿米巴病首先出现的症状，易发生穿孔。
4．阿米巴瘤：阿米巴溃疡深入肌层，病变影响整个肠腔，产生大量肉芽组织，可形主能摸及的大肿块，多位于盲肠，亦见于横结肠、直肠及抗原抗体，极似肿瘤，不易与肠癌区别。偶可引起肠梗阻。
5．其他阿米巴痢疾反复发作后可引起溃疡性结肠炎。有时出现肠套叠，大多位子盲肠结肠交界，可有剧痛与块状物摸及。结肠狭窄在慢性阿米巴痢疾后可出现，但较少见。
6、肝阿米巴病：是指溶组织内阿米巴通过门静脉到达肝脏，引起肝细胞溶化坏死，成为脓肿，通常称为阿米巴肝脓肿，为肠阿米巴病Z多见的并发症，以长期发热、自细胞增加、全身消耗及肝脏肿大与压痛为其主要症状，并易于导致抗原抗体并发症。约半数的阿米巴肝脓肿患者自一周至数年前曾有患类似阿米巴痢疾史。

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

想了解更多的产品及服务请扫描下方二维码：

【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

Clinical manifestations
Common type of onset generally slow, abdominal discomfort, thin stools, sometimes diarrhea, several times a day, and sometimes also constipation. Diarrhea stool slightly when blood-like dysentery-like. Such as lesion development, dysentery-like stool can be increased to 10 to 15 times daily or more, with tenesmus, abdominal pain and bloating. Back to the cecum, transverse colon, especially the rectum may have tenderness, sometimes like ulcer disease or appendicitis. General symptoms are mild, very different from bacillary dysentery. Fecal semen may have small or large amount of trophozoites, stools have anti-stenosis antibodies.
Emergence of amoeblastic liver abscess symptoms, about a few months in the amoeba, a few years, or even a few years later, have never had intestinal amebiasis. Most of the onset gradually gradual, with long-term irregular fever and night sweats and other wasting symptoms mainly in the week before onset to several years may have similar dysentery-like episodes. In laboratory tests, the total number of leukocytes in the early stage of the disease is significantly increased. Neutrophils may exceed 80% between 15,000 and 35,000. If found within the feces nourishment or cysts, the diagnosis will help. Through diagnostic puncture, such as the typical chocolate-like pus can be extracted and found in a summer of crystal and tissue remnants of the mine, the diagnosis can be established, such as re-seizure of amebic trophozoites, the diagnosis is more specific.
complication
There are two types of enteral and parenteral. Extraintestinal complications will be described in hepatomitamiasis and other rare extra-intestinal amoebiasis. The following refers to the enteral complications of amoebiasis.
1. Bowel Perforation: This enalapril is a life-threatening complication. Perforation of the bowel wall lesions can make the contents of the intestine into the abdominal cavity caused by localized or diffuse peritonitis or abdominal abscess, and occasionally because of traumatic penetrance of colonoscopy caused by puncture. Diffuse peritonitis more common, poor prognosis. Mucosal deep ulcers mostly cause chronic perforation, the site more in the cecum, appendix. Traumatic perforation more common in the rectum.
2. Intestinal ulcer deep ulcer: can erode the blood vessels, causing intestinal bleeding of varying sizes, bleeding-threatening life, must be actively rescued and given anti-amoeba drug treatment.
3. Appendicitis: Amoeba can affect the appendix, the clinical manifestations of symptoms similar to the general appendicitis, even can be the first symptoms of intestinal amoebiasis, prone to perforation.
4. Amoeba tumor: amoeba ulcer deep muscular layer, the lesion affects the entire intestine, resulting in a large number of granulation tissue, the main form can touch the large mass, mostly in the cecum, also found in the transverse colon, rectum and antigen antibodies, , Not easy to distinguish with intestinal cancer. Even can cause intestinal obstruction.
5. Repeated attacks of other amoebic dysentery can cause ulcerative colitis. Sometimes intussusception, most of the junction of the cecum colon, there may be pain and block touch. Colon stenosis can occur after chronic amebic dysentery but is less common.
6, hepatic amebiasis: refers to the dissolved tissue of amoeba through the portal vein to reach the liver, causing liver cell necrosis, become abscess, commonly known as amoebiasis abscess, is the most common complication of enteramoma , To long-term fever, increased from the cell, the whole body consumption and enlargement and tenderness of the liver as its main symptoms, and easily lead to antigen-antibody complications. About half of patients with amoebic liver abscess have had a history similar to that of amoebic dysentery from one week to several years ago.