P2X1 Receptor (extracellular) Antibody

分子量：
44980 Da
细胞定位：

形式：
Affinity purified antibody, Liquid
参考文献：
References1. Prasad, M. et al. (2001) J. Physiol. 537, 667.2. Florenzano, F. et al. (2002) Neuroscience 115, 425.3. Ashcroft, F.M. et al. (2000) Ion Channels and Disease Ed 1, p. 405, Academic Press, San Diego.4. Khakh, B.S. et al. (2001) Pharmacol. Rev. 53, 107.5. Ding, Y. et al. (2000) J. Auton. Nerv. Syst. 81, 289.6. Lê, K.T. et al. (1998) J. Neurosci. 18, 7152.7. Robertson, S.J. et al. (2001) Curr. Opin. Neurobiol. 11, 378.8. Dunn, P.M. et al. (2001) Prog. Neurobiol. 65, 107.9. Kim, M. et al. (2001) EMBO J. 20, 6347.10. Burnstock, G. (2001) Trends Pharmacol. Sci. 22, 182.11. Oury, C. et al. (2003) Blood 101, 3969.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality P2X1 Receptor (extracellular) antibody.
功能：

总结：
The P2X receptors belong to the ligand-gated ion channel family and are activated by extracellular ATP.The structure and function of the P2X receptors, investigated mainly usingin vitromodels, indicate their involvement in synaptic communication, cell death, and differentiation.Seven mammalian P2X receptor subtypes (P2X1–P2X7) have been identified and cloned1-3. All P2X receptor subtypes share the same structure of intracellular N- and C-termini two membrane-spanning domains and a large extracellular loop.All P2X receptor subtypes can assemble to form homomeric or heteromeric functional channels with the exception of P2X6, which only seems to function as part of a heteromeric complex4-9.The various P2X receptor subtypes show distinct expression patterns. P2X1-6 have been found in the central and peripheral nervous systems, while the P2X7 receptor is predominantly found in cells of the immune system4. The P2X1 receptor is present in smooth muscle, cerebellum, dorsal horn spinal neurons, and platelets where it is suggested to play a regulatory role duringin vivohomeostasis and thrombosis3,4,10,11.
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