重组人PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9)(C端His标签)

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产品名称：重组人PCSK9(前蛋白转化酶枯草杆菌蛋白酶kexin-9)(C端His标签)
英文名称：Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9
产品货号：JN0841
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln31-Gln152&Ser153-Gln692在C端含有His标签。

PCSK9质量控制：＞95%(还原性SDS-PAGE)

PCSK9制剂：液体

PCSK9保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于PCSK9：
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a means of lowering cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2), and play a role in the neural development.

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