Mouse CD27 Ligand / CD70 Protein (active trimer) (HPLC-verified)

内毒素:
Less than 1.0 EU per μg by the LAL method.

纯度:
>95% as determined by SDS-PAGE.

活性:
Measured by its binding ability in a functional ELISA. Immobilized Mouse CD27, Mouse IgG2a Fc Tag, low endotoxin (Cat. No. CD7-M5252) at 2 μg/mL (100 μL/well) can bind Mouse CD27 Ligand (active trimer) (HPLC-verified) (Cat. No. CDL-M5245) with a linear range of 0.1-4 ng/mL (QC tested).

产品背景:
Cluster of Differentiation 70 (CD70) is also known as CD27 ligand (CD27L / CD27LG), TNFSF7, TNFSF7G, is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and is a surface antigen found on activated T-and B-lymphocytes and mature dendritic cells. Binding of CD70 to its receptor CD27 induces in priming, effector functions, differentiation and memory formation of T-cells, and thus is invloved in the biological processes including T-cell activation, the proliferation of costimulated T-cells, as well as the generation of cytolytic T-cells. CD70 on T cells provides costimulatory signals that are required for T cell proliferation, clonal expansion and the promotion of effector T cell formation. CD70 on mouse B cell has been shown to inhibit terminal differentiation of activated B cells into plasma cells and enhances commitment to memory B cell responses. CD70 induces proliferation and IFNγ production, on NK cells.

产品描述:
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.6 kDa. The protein migrates as 27-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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