重组人小鼠大鼠Irisin(FNDC5)库存

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、YL及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括重组人小鼠大鼠Irisin(FNDC5)库存在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：重组人小鼠大鼠Irisin(FNDC5)库存
品Pai：百奥莱博
英文名：Recombinant Human/Mouse/Rat Fibronectin type III domain-containing protein 5
规格：10μg|50μg|500μg|1mg
编号：JN1487
产地：国产|进口
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp32-Glu143在C端含有His标签。

Irisin/FNDC5质量控制：＞95%(还原性SDS-PAGE)

Irisin/FNDC5制剂：冻干品

Irisin/FNDC5保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Irisin/FNDC5复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Irisin/FNDC5：
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.

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重组人小鼠大鼠Irisin(FNDC5)库存关键词：JN1487,重组人FNDC5,重组人小鼠大鼠Irisin,重组人小鼠大鼠Irisin蛋白,重组小鼠大鼠Irisin


·重组小鼠趋化因子CCL2(MCP-1)(带His标签)
编号：JN0332
英文名称：Recombinant Mouse C-C motif chemokine 2
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Gln24-Asn148在C端含有His标签。

CCL2/MCP-1质量控制：＞95%(还原性SDS-PAGE)。

CCL2/MCP-1制剂：液体

CCL2/MCP-1保存：
收到后请置于-20℃，可稳定保存6个月，避免反复冻融。

关于CCL2/MCP-1：
C-C motif chemokine 2 (CCL2) is a member of the C-C or β chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.


重组人小鼠大鼠Irisin(FNDC5)库存关键词：JN1487,重组人FNDC5,重组人小鼠大鼠Irisin,重组人小鼠大鼠Irisin蛋白,重组小鼠大鼠Irisin

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