PDCD4 Antibody (aa210-221) | LBP62728 | Leading Biology

商品分类：多克隆抗体

产品概述：Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

靶点/蛋白：Human PDCD4. This antibody is expected to recognize all reported isoforms (NP_055271.2; NP_663314.1; NP_001186421.1).

来源：Goat

参考文献：Matsuhashi S.,et al.Res. Commun. Biochem. Cell Mol. Biol. 1:109-120(1997).Azzoni L.,et al.J. Immunol. 161:3493-3500(1998).Ota T.,et al.Nat. Genet. 36:40-45(2004).Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.Deloukas P.,et al.Nature 429:375-381(2004).

特异性：Human, Mouse, Rat, Rabbit, Hamster, Monkey, Chicken, Goat, Horse, Xenopus, Bovine, Guinea Pig, Dog

别名：Programmed cell death protein 4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, PDCD4, H731

应用：ELISA (1:128000), IHC-P (5 μg/ml), WB (0.1-0.3 μg/ml)

简单描述：Goat Polyclonal PDCD4 Antibody (aa210-221). Validated for use in WB, IHC-P, E.

详情：FunctionInhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).Cellular_LocationNucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm. Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457. Exported from the nucleus in the absence of serumTissue_LocationUp-regulated in proliferative cells. Highly expressed in epithelial cells of the mammary gland. Reduced expression in lung cancer and colon carcinoma

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