MYC Antibody (T58) | LBP62494 | Leading Biology

商品分类：多克隆抗体

产品概述：MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of the gene encoding MYC have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene.

靶点/蛋白：This MYC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-65 amino acids from human MYC.

来源：Rabbit

存储溶液：Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

参考文献：Lima,F.P., Am. J. Clin. Pathol. 129 (5), 723-726 (2008)Ida,C., Biosci. Biotechnol. Biochem. 72 (3), 868-871 (2008)Iijima,S., Eur. J. Biochem. 206 (2), 595-603 (1992)

特异性：Human

别名：Myc proto-oncogene protein, Class E basic helix-loop-helix protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription factor p64, MYC, BHLHE39

应用：WB~~1:1000IHC-P~~1:10~50

简单描述：Rabbit Polyclonal MYC Antibody (T58). Validated for use in WB, IHC-P, E.

详情：FunctionTranscription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'- CAC[GA]TG-3'. Activates the transcription of growth-related genes.Cellular_LocationNucleus, nucleoplasm. Nucleus, nucleolus

生物商城：http://www.annoron.com

办公电话：010-56256916

官方售后：400-965-8633

企业 QQ：3212874516、3198592576

地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层