IRR alpha Antibody subunit | LM17211 | Leading Biology

商品分类：单克隆抗体

产品概述：The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesnt bind any of IR and IGF-1R known ligands (1-2). In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown (3).

靶点/蛋白：A synthetic peptide corresponding to residues near the N-terminus of human IRR alpha subunit was used as immunogen.

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. Bolen, J. B., J. S. Brugge. 1997. Annu. Rev. Immunol. 15:371
2. H
3. Zhang B., Roth R. A. J. Biol. Chem., 267: 18320-18328, 1992.


特异性：Human, Mouse, Rat

别名：Insulin receptor-related protein, IRR, IR-related receptor, Insulin receptor-related protein alpha chain, Insulin receptor-related protein beta chain, INSRR, IRR

应用：WB~~1:1000~2000IHC~~1:50~100

简单描述：Rabbit Monoclonal IRR alpha Antibody subunit. Validated for use in WB, IHC. Clone: EP327Y.

详情：FunctionReceptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.Cellular_LocationMembrane; Single-pass type I membrane protein

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