CD4 (T-Helper/Inducer Cell Marker) Antibody - With BSA and Azide | LM14957 | Leading Biology

商品分类：单克隆抗体

产品概述：Recognizes a protein of 55kDa, identified as CD4. It is a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. This protein is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.āThis MAb was characterized as human CD4 antibody at II and IV International Workshop on Human Leukocyte Differentiation Antigens.

来源：Mouse

参考文献：Reinberz EL et al. eds. Leykcocyte Typing II, Springer-Verlag, Berlin, 1985. | Knapp W. et. al. (eds) Leukocyte Typing IV, p314-330, Oxford University Press, Oxford, 1989.Sattentau QJ, et al. The CD4 antigen: physiological ligand and HIV receptor. Cell. 1988, 52(5):631-633. | Gaubin M, et al. Molecular basis of T lymphocyte CD4 antigen functions. Eur J Clin Chem Clin Biochem. 1996, 34(9):723-728.Mazerolles F, et al. Down regulation of T-cell adhesion by CD4. Hum Immunol. 1991, 31(1):40-6

特异性：Human, Chimpanzee

别名：T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3, CD4, CD4

简单描述：Mouse Monoclonal CD4 (T-Helper/Inducer Cell Marker) Antibody - With BSA and Azide. Validated for use in IF, FC. Clone: EDU-2.

详情：FunctionAccessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.Cellular_LocationCell membrane; Single-pass type I membrane protein Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum

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