ANPEP/CD13 Antibody (Ascites) | LM13453 | Leading Biology

商品分类：单克隆抗体

产品概述：Aminopeptidase N is located in the small-intestinal andrenal microvillar membrane, and also in other plasma membranes. Inthe small intestine aminopeptidase N plays a role in the finaldigestion of peptides generated from hydrolysis of proteins bygastric and pancreatic proteases. Its function in proximal tubularepithelial cells and other cell types is less clear. The largeextracellular carboxyterminal domain contains a pentapeptideconsensus sequence characteristic of members of the zinc-bindingmetalloproteinase superfamily. Sequence comparisons with knownenzymes of this class showed that CD13 and aminopeptidase N areidentical. The latter enzyme was thought to be involved in themetabolism of regulatory peptides by diverse cell types, includingsmall intestinal and renal tubular epithelial cells, macrophages,granulocytes, and synaptic membranes from the CNS. Humanaminopeptidase N is a receptor for one strain of human coronavirusthat is an important cause of upper respiratory tract infections.Defects in this gene appear to be a cause of various types ofleukemia or lymphoma.

靶点/蛋白：This ANPEP/CD13 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 156-184 amino acids from human ANPEP/CD13.

来源：Mouse

存储溶液：Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

参考文献：Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Curnis, F., et al. J. Biol. Chem. 285(12):9114-9123(2010)Wang, X., et al. PLoS ONE 5 (8), E11934 (2010) :Ito, S., et al. Gen Thorac Cardiovasc Surg 57(11):591-598(2009)Ju, S., et al. Cell Cycle 8(16):2578-2585(2009)

特异性：Human

别名：Aminopeptidase N, AP-N, hAPN, Alanyl aminopeptidase, Aminopeptidase M, AP-M, Microsomal aminopeptidase, Myeloid plasma membrane glycoprotein CD13, gp150, CD13, ANPEP, APN, CD13, PEPN

应用：WB~~1:100~1600

简单描述：Mouse Monoclonal ANPEP/CD13 Antibody (Ascites). Validated for use in WB, E. Clone: 505CT12.1.2.

详情：FunctionBroad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.Cellular_LocationCell membrane; Single-pass type II membrane protein. Cytoplasm, cytosol. Note=A soluble form has also been detectedTissue_LocationExpressed in epithelial cells of the kidney, intestine, and respiratory tract; granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood- brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients

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企业 QQ：3212874516、3198592576

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