商品分类:单克隆抗体
产品概述:PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. PI3-K consists of two subunits; p85 and p10. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K (1-2). Four isoforms of p110 has been found; α, β, γ, and the Δ subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene (3) that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach (4-5). Three hot spot mutations (E542K and E545K; and H1047R) make p110α a potential drug target.
靶点/蛋白:A synthetic peptide of human near the C-term of PI3-K p110 alpha was used as an immunogen.
来源:Rabbit
存储溶液:50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
参考文献:1. Otsu et al. (1992) Cell 65, 91-104
2. Hiles et al. (1991) Cell 70, 419-429
3. Chang HW, Aoki M, Fruman D, et al. Science 1997;276:1848
4. Depowski PL, Rosenthal SI, Ross JS. Mod Pathol 2001;14:672
5. Bose S, Crane A, Hibshoosh H, Mansukhani M, Sandweis L, Parsons R, Hum Pathol 2002;33:405
特异性:Human
别名:Phosphatidylinositol 4, 5-bisphosphate 3-kinase catalytic subunit alpha isoform, PI3-kinase subunit alpha, PI3K-alpha, PI3Kalpha, PtdIns-3-kinase subunit alpha, Phosphatidylinositol 4, 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha, PtdIns-3-kinase subunit p110-alpha, p110alpha, Phosphoinositide-3-kinase catalytic alpha polypeptide, Serine/threonine protein kinase PIK3CA, PIK3CA
应用:WB~~1:5000~20000
简单描述:Rabbit Monoclonal PI3-kinase (p110) Antibody (subunit alpha). Validated for use in WB, IF. Clone: EP383Y.
详情:FunctionPhosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to various growth factors. Involved in the activation of AKT1 upon stimulation by receptor tyrosine kinases ligands such as EGF, insulin, IGF1, VEGFA and PDGF. Involved in signaling via insulin-receptor substrate (IRS) proteins. Essential in endothelial cell migration during vascular development through VEGFA signaling, possibly by regulating RhoA activity. Required for lymphatic vasculature development, possibly by binding to RAS and by activation by EGF and FGF2, but not by PDGF. Regulates invadopodia formation in breast cancer cells through the PDPK1- AKT1 pathway. Participates in cardiomyogenesis in embryonic stem cells through a AKT1 pathway. Participates in vasculogenesis in embryonic stem cells through PDK1 and protein kinase C pathway. Has also serine-protein kinase activity: phosphorylates PIK3R1 (p85alpha regulatory subunit), EIF4EBP1 and HRAS.
生物商城:http://www.annoron.com
办公电话:010-56256916
官方售后:400-965-8633
企业 QQ:3212874516、3198592576
地 址:北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
温馨提示:不可用于临床ZL。