NR3C1/Glucocorticoid Receptor Antibody (clone 6E6) | LM12626 | Leading Biology

商品分类：单克隆抗体

产品概述：Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.

靶点/蛋白：Human GR / Glucocorticoid Receptor

来源：Mouse

参考文献：Hollenberg S.M.,et al.Nature 318:635-641(1985).Encio I.J.,et al.J. Biol. Chem. 266:7182-7188(1991).Wang W.,et al.Nucleic Acids Res. 39:44-58(2011).Turner J.D.,et al.Ann. N. Y. Acad. Sci. 1095:334-341(2007).Munroe D.G.,et al.Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases.

特异性：Human

别名：Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL

应用：ELISA (1:10000), Flo (1:200-1:400), ICC (1:200-1:1000), IF (1:1000), IHC-P (1:200), WB (1:500-1:2000),

简单描述：Mouse Monoclonal NR3C1/Glucocorticoid Receptor Antibody (clone 6E6). Validated for use in WB, IHC-P, IF, ICC, E, Flo. Clone: 6E6.

详情：FunctionReceptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.Cellular_LocationCytoplasm. Mitochondrion. Nucleus Note=Cytoplasmic in the absence of ligand, nuclear after ligand- bindingTissue_LocationWidely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.

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