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产品编号:
120-01
别名:
BMP-14,Cartilage-Derived Morphogenetic Protein-1 (CDMP-1)
描述:
GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 354 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids. License: This product is produced solely by PeproTech Inc. under a license from Biopharm GmbH, Germany. Biopharm GmbH is not responsible for the quality or fitness for use of this product. It may be used only for research purposes and may neither be used in humans nor for veterinary purposes. This product may not be used for commercial purposes.
氨基酸序列:
APSATRQGKR PSKNLKARCS RKALHVNFKA PSATRQGKRP SKNLKARCSR KALHVNFKDM GWDDMGWDDW IIAPLEYEAF HCEGLCEFPL RSHLEPTNHA VIQTLMNSMD PESTPPTCCV PTRLSPISIL FIDSANNVVY KQYEDMVVES CGCR
来源:
E.coli
纯度:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
生物活性:
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
温馨提示:不可用于临床ZL。