C045 Cyclosporin D, EvoPure/环孢菌素D, EvoPure

Cyclosporin D, EvoPure/环孢菌素D, EvoPure
产品编号：C045 
产品规格：5mg

CAS Number	63775-96-2
Molecular Formula	C63H113N11O12
Molecular Weight	1216.63 g/mol
Form	Powder
Appearance	Colorless prisms
Purity Level	≥95.0%
Solubility	DMSO: Soluble Ethanol: Soluble
Source	Tolypocladium Inflatum
Boiling Point	1294.741 °C
Melting Point	148 -151 °C
Flash Point	736.833 °C
Storage Conditions	2-8 °C

Description
Cyclosporin is an immunosuppressive cyclic polypeptide drug commonly used post-transplant to prevent graft rejection from the cytotoxic effects of T-cells.
TOKU-E offers seven forms of cyclosporin: cyclosporin A,EvoPure?, cyclosporin B, EvoPure?, cyclosporin C, EvoPure?, cyclosporin D, EvoPure?, cyclosporin E, EvoPure?, cyclosporin H, EvoPure?, and cyclosporin L, EvoPure?. Cyclosporin is soluble in DMSO and ethyl alcohol. EvoPure? products are purified single antibiotic fractions, most >99% pure.
Mechanism
Cyclosporins bind to the intercellular lymphocyte protein called cyclophilin. Cyclosporine:cyclophilin complexes target calcineurin, a protein-phosphatase which activates T-cells and ultimately prevents T-cell maturation and cytotoxic damage.
Mammalian Biology Applications
Cyclosporins are used to prevent damage to normal func