CDH2 / N Cadherin Antibody (clone 5D5) | LM11745 | Leading Biology

商品分类：单克隆抗体

产品概述：Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).

靶点/蛋白：Human CDH2

来源：Mouse

参考文献：Reid R.A.,et al.Nucleic Acids Res. 18:5896-5896(1990).Reid R.A.,et al.Submitted (NOV-1990) to the EMBL/GenBank/DDBJ databases.Salomon D.,et al.J. Cell Sci. 102:7-17(1992).Ota T.,et al.Nat. Genet. 36:40-45(2004).Nusbaum C.,et al.Nature 437:551-555(2005).

特异性：Human, Mouse, Rat

别名：Cadherin-2, CDw325, Neural cadherin, N-cadherin, CD325, CDH2, CDHN, NCAD

应用：IF (1:200-1:1000), IHC-P (1:200), WB (1:500-1:2000)

简单描述：Mouse Monoclonal CDH2 / N Cadherin Antibody (clone 5D5). Validated for use in WB, IHC-P, IF, E. Clone: 5D5.

详情：FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density (By similarity).Cellular_LocationCell membrane; Single-pass type I membrane protein

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