E-Cadherin Antibody Phospho (pS838/840) | LM11916 | Leading Biology

商品分类：单克隆抗体

产品概述：E-Cadherin, a member of the cadherin superfamily, is implicated as a key player in different cellular processes including development, morphology, polarity, migration and tissue integrity (1-2). E-cadherin is a glycoprotein with an extracellular domain that interacts with other E-cadherin molecules on adjacent cells, thereby establishing adhesion between epithelial cells. Established as a tumor and metastasis suppressor, E-cadherin expression is frequently down-regulated or extinguished in malignancy which strongly correlates with poor prognosis (3-4). Mutations in E-cadherin are found in gastric, breast, colorectal, thyroid and ovarian cancer (5).

靶点/蛋白：A phospho-specific peptide corresponding to residues surrounding serine 838/840 of human E-cadherin was used as an immunogen. This antibody detects E-cadherin phosphorylated at serine 838 and 840

来源：Rabbit

存储溶液：50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

参考文献：1. Mansouri, A.; Goodfellow, P. N.; Kemler, R. : Cytogenet. Cell Genet. 46: 655, 1987.
2. Vleminckx K, Kemler R. Bioessays. 1999;21:211
3. Nollet, F., G. Berx, and F. van Roy. 1999. Mol. Cell Biol. Res. Comm. 2:77
4. Birchmeier, W., and J. Behrens. 1994. Biochim. Biophys. Acta. 1198:11
5. Thoreson MA, Reynolds AB. Differentiation. 2002 Dec;70(9-10):583-9


特异性：Human, Mouse, Rat

别名：Cadherin-1, CAM 120/80, Epithelial cadherin, E-cadherin, Uvomorulin, CD324, E-Cad/CTF1, E-Cad/CTF2, E-Cad/CTF3, CDH1, CDHE, UVO

应用：WB~~1:2000IHC~~1:100

简单描述：Rabbit Monoclonal E-Cadherin Antibody Phospho (pS838/840). Validated for use in WB, IHC. Clone: EP913(2)Y.

详情：FunctionCadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7.Cellular_LocationCell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membraneTissue_LocationNon-neural epithelial tissues.

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